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#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?
“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha
Fasting and cancer
The purpose of the study was to find out if fasting could protect the intestines from high-dose radiation, which could allow for higher doses of radiation treatment in killing pancreatic tumor cells.
#62 – Keith Flaherty, M.D.: Deep dive into cancer— History of oncology, novel approaches to treatment, and the exciting and hopeful future
“We can’t keep hitting the same pillar and expect that we’re going to cure cancer. . .we need the activators of the immune system, we need the inhibitors of the activated oncogenes, we need the drugs that target epigenetic regulators, and we need the metabolic switch regulators.” — Keith Flaherty
#61 – Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiology
“This is where an MRI becomes a beautiful machine in the fact that it actually allows you to take the ‘yes or no’ binary answer of functional nuclear medicine and combine it with the anatomic localization and understanding of tissue types of radiology. . .I merged those two together on the one machine.” — Raj Attariwala
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
#52 – Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone – two topics that are surprising interrelated
“Primary prevention is still very much art and not science and probably will be for our lifetime so we’ll have to get used to that.” —Ethan Weiss
#51 – Robert Sapolsky, Ph.D.: The pervasive effect of stress – is it killing you?
“The [stress response] system has been serving vertebrates, doing a lot of help for them for an awful long time, and it’s only been a very recent modification to instead secrete [cortisol] in response to thinking about taxes.” —Robert Sapolsky
#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it)
“If there is one central, common pathway through which we can understand almost all aspects of the deleterious impact of insufficient sleep, it is…an excessive leaning on the fight or flight branch of the nervous system.” — Matthew Walker
Red meat, cancer, push-ups, and CVD
Groundhog Day (GD) came and went last month — and sure enough — 2019 has already brought a bounty of emails and Tweets from concerned folks wondering if red meat is going to kill them (again).
#42 – Avrum Bluming, M.D. and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer
“We welcome the criticism and the discussion, that way we will all learn. We don’t claim to have the final answer, but we think that this book [Estrogen Matters] represents an important step forward in empowering women and helping them live longer and live better.” —Avrum Bluming