Metformin and exercise – déjà vu all over again?
Metformin blunts muscle hypertrophy in response to progressive resistance training
#67 – AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more
“If you are genetically blessed to become a centenarian, the gift you got is that you have genes that delay your receipt of chronic disease by what appears to be about 20 years.” — Peter Attia
#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?
“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha
#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness
“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective. . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung
Metformin and exercise
If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.
Ketones, fasting, and muscle loss
I read an interesting article authored by my friend Dom D’Agostino and his colleagues on the anti-catabolic effects of ketone bodies in skeletal muscle.
#31 – Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
“I pay more attention today to stress than anything else.” —Nav Chandel
Easter Island, inflammation, and ask me anything
The implications of the story are frightening, but kudos to the correspondent and photographer that put this story together.
#24 – Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
“Use the correct terminology with everything.” –Tom Dayspring
#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system
“Neurons like to be tickled, not bludgeoned.” —Rob Lustig