#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin
“It’s really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it’s difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein
#204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D.
“If you prevent aging and age-related disease, you’re going to compress morbidity, too.” — Nir Barzilai
#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules
“I never thought [extending the human lifespan] was going to happen because we got better at treating cancer or we got better at preventing heart disease. I always thought it was going to happen because we would develop something … that would fundamentally change the rate of aging. And we haven’t developed that yet. We’ve got a lot of clues and I think we’re getting closer and closer and closer.” —Steve Austad
Does NMN improve metabolic health in humans?
Thoughts on the first efficacy trial recently published
#70 – David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)
In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of…
#35 – Nir Barzilai, M.D.: How to tame aging
“I think the prevention of aging is really a good place to be. . .and I think life is going to be very different in the next decade with our advances.” —Nir Barzilai
#27 – David Sinclair, Ph.D.: Slowing aging – sirtuins, NAD, and the epigenetics of aging
“This is a lesson for anyone who’s listening who thinks that getting to somewhere like this is easy. You have to be massively determined, you have to have grit, and I just wouldn’t give up because there’s nothing else I want to do in my life.” —David Sinclair
#26 – AMA #3: supplements, women’s health, patient care, and more
“In case you haven’t guessed yet, there’s been a lot of drug traffic on the beach. And I’m not talking about Robitussin and No-Doze. I’m talking about the hard stuff, and a lot of it. I’ve been trying to find out who’s behind it. It hasn’t been easy. I don’t shower much.” —Irwin M. Fletcher