Insulin Resistance

Insulin resistance (IR) is a topic that’s been of paramount interest in medical research for nearly a century. Insulin is a pancreatic hormone which plays key roles in the metabolism of carbohydrates and fats.

What is Insulin Resistance? When tissues become less responsive to the effects of insulin, the pancreas must produce more and more insulin to maintain glucose homeostasis; this state is the definition of insulin resistance. IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions.

How can we prevent IR from developing, and can it be reversed? IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions, ranging from atherosclerotic cardiovascular disease to Alzheimer’s disease to cancer to fatty liver disease. These threats underscore the critical importance of IR prevention and mitigation (or even reversal) as part of the effort toward extending lifespan and healthspan.

Below is a compilation of podcasts, clips, and articles focused on insulin resistance, what it means, and strategies for prevention and treatment.

“I think the prevention of aging is really a good place to be. . .and I think life is going to be very different in the next decade with our advances.” —Nir Barzilai

“I’ve always felt that it was really somehow an enormous opportunity and a gift to be able to pursue this down to the level that I’ve been able to do in the past 30 years.” —Rudy Leibel

“Neurons like to be tickled, not bludgeoned.” —Rob Lustig

If you’re reading this, you probably know that I’m obsessed with longevity.

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Insulin Resistance

#35 – Nir Barzilai, M.D.: How to tame aging

#33 – Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system

Is Type 2 Diabetes Reversible at Scale?