Insulin Resistance

Insulin resistance (IR) is a topic that’s been of paramount interest in medical research for nearly a century. Insulin is a pancreatic hormone which plays key roles in the metabolism of carbohydrates and fats.

What is Insulin Resistance? When tissues become less responsive to the effects of insulin, the pancreas must produce more and more insulin to maintain glucose homeostasis; this state is the definition of insulin resistance. IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions.

How can we prevent IR from developing, and can it be reversed? IR has long been infamous for its central role in the pathogenesis of type II diabetes, but we now know that IR is also involved in the development of a host of other life-threatening conditions, ranging from atherosclerotic cardiovascular disease to Alzheimer’s disease to cancer to fatty liver disease. These threats underscore the critical importance of IR prevention and mitigation (or even reversal) as part of the effort toward extending lifespan and healthspan.

Below is a compilation of podcasts, clips, and articles focused on insulin resistance, what it means, and strategies for prevention and treatment.

“I’ve always felt that it was really somehow an enormous opportunity and a gift to be able to pursue this down to the level that I’ve been able to do in the past 30 years.” —Rudy Leibel

“Neurons like to be tickled, not bludgeoned.” —Rob Lustig

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Insulin Resistance

#33 – Rudy Leibel, M.D.: Finding the obesity gene and discovering leptin

#14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system

Is Type 2 Diabetes Reversible at Scale?