Learn more about Peter Attia’s digital program
Where a study on metformin and cardiovascular disease fell short – and what it can teach us
An investigation on metformin, diabetes, lipid biology, and cardiovascular disease offered little insight on any of these topics, but it illustrates common problems in scientific research
Can a father’s metformin cause birth defects in his sons?
Several studies have examined the effects of both maternal diabetes and maternal metformin exposure on offspring, but prospective fathers have received comparatively little attention. A recent study sought to change that.
#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?
“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha
Metformin and exercise
If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.
#103 – Looking back on the first 99 episodes: Strong Convictions, Loosely Held
“I reserve metformin prescriptions for patients who obviously are in need of it from the standpoint of glucose and insulin regulation, but I don’t view it really as a pro longevity agent yet.” — Peter Attia
#148 – Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program
“I don’t really care what causes aging. What I care about is: What is the process that can postpone all the different aspects of aging?” — Rich Miller
#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman
#216 – Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.
“My big hope is that we’re going to be able to have some combination of directed, metabolic immune supplements and diet that really work with therapy to treat cancer.” —Josh Rabinowitz
Metformin and COVID-19 mortality risk; a timeline of Kobe’s last day
A few things worth checking out: 03-28-2021
#67 – AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more
“If you are genetically blessed to become a centenarian, the gift you got is that you have genes that delay your receipt of chronic disease by what appears to be about 20 years.” — Peter Attia