July 2, 2018

Podcast

Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more (EP.02)

"If you’re doing something of quality, and are passionate about it, and you put in the work, people will notice it." —Rhonda Patrick

by Peter Attia

Read Time 7 minutes

Rhonda Patrick, Ph.D. and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We visit IGF-1 and whether there’s a tradeoff between having high or low levels. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD+ booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality? We dig into those questions…and a lot more.

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Rhonda is a wealth of knowledge and was the perfect companion to explore several interesting topics in this episode. She puts a great deal of thought and effort into her research, and it really shows in this conversation.

We discuss:

  • What Rhonda believes differently today than she did a few years ago;
  • The paradox of GH/IGF-1 in performance and longevity;
  • The role of PPAR in fat metabolism and ketogenic diets;
  • The possible genetic explanations for why some patients don’t respond well to a ketogenic diet;
  • The health benefits of heat and cold exposure;
  • NAD+; and
  • More.

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