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#176 – AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevity
“If you have the aspiration of kicking ass when you’re 85, you can’t afford to be average when you’re 50.” —Peter Attia
#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.
“[Rapamycin] is the most robust and reproducible drug that we know about today for impacting not only longevity, but to the extent that we can measure various metrics of healthspan in complex animals, rapamycin also seems to positively impact pretty much every aspect of health span that we measure.” —Matt Kaeberlein
#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.
“It’s really important that we be willing to change our beliefs about nutrition and other aspects of health as more data comes in.” —Matt Kaeberlein
Muscle Mass and Cognitive Function
A recent narrative review hypothesizes a key role for myokine disruption caused by physical inactivity.
Can a new drug mimic the effects of exercise on bone and muscle?
Researchers have recently discovered that a new drug called locamidazole may help to prevent loss of bone density and muscle mass during periods of inactivity, but it’s no substitute for all of the benefits of exercise.
#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.
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With exercise, results matter more than “time served”
How much time should a person spend exercising? However long it takes to see meaningful improvements in VO₂ max and strength
Resistance training partially reverses some of the hallmarks of aging type II muscle fibers
Age-related muscle declines are not as inevitable as you might think.
Optimizing protein quantity, distribution, and quality
Maximizing muscle protein synthesis is more than a matter of daily protein intake. How we distribute protein throughout the day matters, as does protein quality.
#276 ‒ Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more
“One of the most important things to understand when you are using some sort of intervention is, do you have a biomarker to know if you’re doing it correctly?” —Peter Attia