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Metformin and exercise
If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.
#73 – AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more
“The sky is blue, and the trees are green; therefore, I should eat cyanide.” — Peter Attia on the type of brilliant logic people use to suggest you burn more calories while sleeping vs. exercising
#85 – Iñigo San Millán, Ph.D.: Zone 2 Training and Metabolic Health
“What I have been seeing for 25 years, working with elite athletes, is that [zone 2] is the exercise intensity where I see the biggest improvement in fat burning and the biggest improvement in lactic clearance capacity. Therefore, that means that the mitochondria is where you see the biggest improvement.” —Iñigo San Millán, Ph.D.
#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book
“It’s not time that heals all wounds. It’s actually time during REM sleep and dreaming that provides this emotional convalescence.” — Matthew Walker, Ph.D.
#132 – AMA #16: Exploring hot and cold therapy
“All of the work that went into this analysis earlier in the year, it really changed my tune. And I think I’m now at the point where I kind of want to have a sauna, frankly, in the tool kit for longevity.” — Peter Attia
#175 – Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging process
“I don’t think I will ever understand aging fully. And I don’t think the field will. … But I also believe that we don’t have to understand it fully to be able to have an impact on the biology of aging through interventions.” —Matt Kaeberlein
A Game Plan for Healthy Enjoyment of the Holidays
Lessons from my annual showdown with pie.
#199 – Running, overcoming challenges, and finding success | Ryan Hall
“You just got to bring yourself back to being present in this moment, and there’s always enough to get you through this moment.” —Ryan Hall
#200 – AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more
“Anytime I’m not drinking [plain] water, there’s really a purpose that I’m trying to serve in terms of glucose and/or electrolyte replacement and improving hydration status and water absorption.” —Peter Attia
#201 – Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2)
“You can accomplish very important mitochondrial adaptations and very important metabolic adaptations by exercising one hour.” —Iñigo San-Millán