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#196 – AMA #32: Exercise, squats, deadlifts, BFR, and TRT
“You have to differentiate between signal and noise. . .it’s easy to say testosterone causes heart disease just like it’s easy to say estrogen causes breast cancer. But if you’re actually going to go through all of the data. . .I think it becomes very difficult to make that case.” —Peter Attia
Is alternate-day fasting superior to calorie restriction for fat loss in lean adults?
A recent study suggests ADF is no magic bullet
#171 – Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective molecules
“I never thought [extending the human lifespan] was going to happen because we got better at treating cancer or we got better at preventing heart disease. I always thought it was going to happen because we would develop something … that would fundamentally change the rate of aging. And we haven’t developed that yet. We’ve got a lot of clues and I think we’re getting closer and closer and closer.” —Steve Austad
#145 – AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctor
In this “Ask Me Anything” (AMA) episode, Peter and Bob take a deep dive into zone 2 training. They begin…
#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications
“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman
#127 – AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more
“Could we think that sleep could now provide a contribution to this Horvath clock of determining your biological age? . . .I think it probably does.” —Matthew Walker, Ph.D.
A few things worth sharing: 08-30-2020
Shitty first drafts and accelerating fasts.
#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein
#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White