Category

Nutritional Biochemistry

I often get asked, ‘Which diet works best?’. In my view, this is simply the wrong question. Nutritional biochemistry is a powerful lever in our longevity toolkit, but it is much more than fad diets or the number on the bathroom scale. A better question might be, “how can I use nutrition to support my metabolic health?”

Reframing the goal toward metabolic health is a critical starting point. From there, you can combine general principles of nutrition science (such as how much protein you need) with personalization tactics (such as using a CGM to monitor glucose levels) to build a nutrition plan that makes sense for you.

See the collection of audio clips, podcasts, and articles below to learn more about my nutrition and fasting framework.

Fasting and cancer

The purpose of the study was to find out if fasting could protect the intestines from high-dose radiation, which could allow for higher doses of radiation treatment in killing pancreatic tumor cells.

Cortisol and cross-pollination

Cortisol is a hormone I’ve been paying a lot more attention to of late.

Fast-breaking without glucose spiking

As I’m coming off of a week of fasting and heading into a week of a ketogenic diet, the timing seems right to address the question of how I break a longer-term fast and the responses that some people get.

Is there an optimal window of time-restricted feeding?

Breakfast like a king, lunch like a prince, and dine like a pauper?

European Vacation

I know I’m not alone in sensing this, as I’ve had this discussion with at least a dozen friends over…

#59 – Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness

“We think of all these responses, obesity, insulin resistance, and the beta cell failure, as pathologic. They’re actually protective.  . .Your body is actually trying to protect itself against the root cause of the problem which is too much insulin, too much glucose.” — Jason Fung

#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleep

“[Sleep] is like that master volume button on a mixing deck that you see in the studio. You can manipulate each one of those dials, or you can go to the far left and just move that one dial…and all of the other levers seem to move with it.” — Matthew Walker

#53 – AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and more

“Time is the only truly finite resource that we have. It is also the only unifying, equalizing resource. Meaning, no matter how much wealth or smarts or whatever you have, we are all stuck with the same disappearing thing.” — Peter Attia

The Bad Science Behind ‘Skipping Breakfast’

Bad science is an abomination. Incompetent news reporting on bad science is worse.

#46 – Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease – NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine and more

“People are gonna make a decision to. . . either wait 10 or 20 years until we know something better, or you take the position that you’re going to tinker. And if you’re going to tinker, you’re a lot more successful if you have a working model of what’s going on than if you don’t.” —Chris Masterjohn

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