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diabetes

Medications, Supplements & Other Treatments

Metformin and exercise

If you like concrete answers and absolutes, longevity is not a fun sandbox to play in.

Medications, Supplements & Other Treatments

Metformin and exercise – déjà vu all over again?

Metformin blunts muscle hypertrophy in response to progressive resistance training

Fasting

#80 – Celebrity AMA with Apolo Ohno and Sasha Cohen: Fasting, rapamycin, performance vs. longevity, and more

“I am obsessed with knowing stuff. There’s just no denying it.” — Peter Attia

Preventing Chronic Disease

#91 – Eric Topol, M.D.: Can AI empower physicians and revolutionize patient care?

“If we lean on machines more. . .we can free up time with patients and we could get the doctor-patient relationship back to where it ought to be.” —Eric Topol, M.D.

Medications, Supplements & Other Treatments

#103 – Looking back on the first 99 episodes: Strong Convictions, Loosely Held

“I reserve metformin prescriptions for patients who obviously are in need of it from the standpoint of glucose and insulin regulation, but I don’t view it really as a pro longevity agent yet.” — Peter Attia

Science of Aging

#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David

Fasting

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

Ketosis

#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino

COVID-19

#117 – Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

“There’s really no evidence so far that says this virus has changed in a way that makes it unlikely a vaccine will work, unlikely that a previous infection will protect you from a second infection–there may be reasons why it won’t, but it won’t be because the virus is changing.” — Stanley Perlman

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