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#247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D.
“If everybody got truly optimal medical therapy, if we didn’t have barriers to using all these tools in everybody, I think this disease would largely be controlled.” —Ethan Weiss
Twenty Years of the Human Genome: Growing Older and Wiser
In the 20 years since the Human Genome Project was completed in 2003, we’ve dramatically expanded our understanding of the impact of genetics on human health, but the work is far from finished.
#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.
“It’s so important for women to understand that the absolute risks of these hormones are much lower in early menopause than in later menopause.” —JoAnn Manson
#173 – AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions
“Zone two is a metabolic state. It’s not determined by speed. It’s determined by which energy system you’re requiring and what the equilibrium is.” —Peter Attia
Separating substance from nonsense in a study on NMN supplements
A recent randomized trial investigated the effect of NMN supplementation on NAD levels, biological aging, and exercise performance. What can we believe from their results?
#261 ‒ Training for The Centenarian Decathlon: zone 2, VO2 max, stability, and strength | Peter Attia, M.D.
“I would never want anybody to come away from this thinking, ‘I’m too old to do anything about it.’ I think as long as you’re breathing, you have a chance to do something about it.” —Peter Attia
First anti-inflammatory medication approved for treatment of ASCVD
Low-dose colchicine, an anti-inflammatory drug, was recently approved by the FDA to reduce risk of cardiovascular events
#270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers
“This paper basically addresses how our beliefs about the drugs we take impacts how they affect us at a real level, not just at a subjective level, but at a biological level.” —Andrew Huberman
How does APOE status impact the relationship between obesity and dementia risk?
Obesity has been reported by some to increase risk of dementia, while other studies have reported that obesity is protective against dementia. Might the effects of APOE genotype help to explain the discrepancy?
#285 – AMA #55: Exercise: longevity-focused training, goal setting, improving deficiencies, managing emotional stress, and more
“Nothing comes close to having a greater impact on the length and quality of your life than your training. And unfortunately, we can’t put it in a pill. You’ve got to be able to do it. There’s no biohack for it.” —Peter Attia