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Alzheimer

Exercise & Physical Health

#193 – AMA #31: Heart rate variability (HRV), alcohol, sleep, and more

In this “Ask Me Anything” (AMA) episode, Peter and Bob first answer a variety of questions related to heart rate…

Cardiovascular Disease

#210 – Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

I think we should advise people to measure Lp(a); that would be a gigantic step.” —Benoît Arsenault

Metabolic disease

Metabolic dysfunction case study and a framework for metabolic health

This audio clip is from “Ask Me Anything” (AMA) episode #15 — Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more, originally…

Body Composition

#212 – The neuroscience of obesity | Stephan Guyenet, Ph.D.

This system works better at protecting against fat loss than it does against fat gain.” —Stephan Guyenet

Sleep

#221 ‒ Understanding sleep and how to improve it

Sleep is the greatest life support system you could ever wish for. It’s a remarkable health insurance policy, it’s largely democratic, free and largely painless.” —Matt Walker

Science of Aging

#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more

You can’t solve or even attempt to solve complicated problems if you aren’t asking the right questions and you don’t have the right frameworks.” —Peter Attia

Medications, Supplements & Other Treatments

#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.

If you bring me a patient with concussion, I can pretty much tell you I can get that patient better. There are highly effective treatments with this injury.” —Micky Collins

Medications, Supplements & Other Treatments

#279 – AMA #53: Metabolic health & pharmacologic interventions: SGLT-2 inhibitors, metformin, GLP-1 agonists, and the impact of statins

It is worth noting, and this is a very important question, that it does not appear that the effect of statins on insulin resistance is a function of lipids being lowered.” —Peter Attia

Preventing Chronic Disease

How does APOE status impact the relationship between obesity and dementia risk?

Obesity has been reported by some to increase risk of dementia, while other studies have reported that obesity is protective against dementia. Might the effects of APOE genotype help to explain the discrepancy?

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