Learn more about Peter Attia’s digital program
Coronary artery calcium scan
After last week’s deep dive into the relationship between LDL cholesterol, systolic blood pressure, and cardiovascular disease, I thought it…
The straight dope on cholesterol – Part VIII
In this post we’ll double-click on a paper covering cholesterol and heart disease risk factors.
#69 – Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly
“The way we raise our kids early on might actually set a pattern for how much of an accelerated life, or how much of a stressed out nervous system they might have later on. . . a lot of the behavioral patterns that we’re instilling in our kids are kind of setting the foundation for insulin resistance and inflammation early on.” —Ronesh Sinha
#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.
“[Rapamycin] is the most robust and reproducible drug that we know about today for impacting not only longevity, but to the extent that we can measure various metrics of healthspan in complex animals, rapamycin also seems to positively impact pretty much every aspect of health span that we measure.” —Matt Kaeberlein
#35 – Nir Barzilai, M.D.: How to tame aging
“I think the prevention of aging is really a good place to be. . .and I think life is going to be very different in the next decade with our advances.” —Nir Barzilai
#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
“I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there’s a better immune response and your symptoms will be milder.” — Joan Mannick
#238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease
“ApoB is a necessary, though not sufficient, factor in the development of ASCVD which means the more you lower it, the more you lower risk. Full stop.” —Peter Attia
#259 – Women’s sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D.
“I can’t tell you how many women soldier on either avoiding sex or in pain because they don’t either know or feel validated to seek treatment.” —Sharon Parish
#87 – Rick Johnson, M.D.: Metabolic Effects of Fructose
“Fructose turns out to be used by animals as a mechanism to store fat.” — Rick Johnson
#167 – Gary Taubes: Bad science and challenging the conventional wisdom of obesity
“Doing a background analysis is the hard, relentless, rigorous grunt work of science. It’s endless and thankless, because if you do it right, all you’ll do is prove that you were wrong all along.” —Gary Taubes