Category

Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

A new frontier for early cancer detection?

Discussing the GRAIL blood test

#169 – Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigation

“There is no smoking gun per se. What there is is smoke coming out of a lot of windows. … There is enough smoke coming out of enough windows that we cannot take the lab leak hypothesis off the table, and so for me, the most credible people on this, they’re not saying it was a lab leak. What they’re saying is, ‘Why can’t we have a full investigation?’”  —Katherine Eban

#166 – Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic disease

“You can maintain optimal oral health just by brushing teeth, by flossing really well, and having good nutrition.” —Pat Corby

Are continuous glucose monitors a waste of time for people without diabetes?

Some experts suggest CGMs are useless for nondiabetics. I disagree.

#165 – AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGM

“Hyperinsulinemia on an [oral glucose tolerance test], even in the presence of normoglycemia, is the canary in the coal mine.” —Peter Attia

A hope for treating Alzheimer’s disease?

The FDA approves the first new medication for AD, aducanumab, in two decades

#164 – Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementia

“At the end of the day, it really has to do with how people see themselves, how people interact with the world, what kind of relationships they have, how able they are to let go of things that they’ve lost and how able they are to focus on the positive.”  —Amanda Smith

#162 – Sarah Hallberg, D.O., M.S.: Challenging the status quo of treating metabolic disease, and a personal journey through a grim cancer diagnosis

For a disease that everyone thought was chronic and progressive, to see people recover from it is quite astounding.” —Sarah Hallberg

Does NMN improve metabolic health in humans?

Thoughts on the first efficacy trial recently published

#160 – Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variants

“If you ask me the question, ‘What do I fear most about this whole pandemic?’ it’s actually not the variants. … It’s that there would be a significant percentage of the population that is going to choose not to vaccinate so much so that we can’t get to that 80+% of population immunity we need to slow this virus.” —Paul Offit

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