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Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

#147 – Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3s

“What’s important is in science, you always have to be skeptical and you always need to find whether any particular study can be replicated or not before you make strong recommendations and adopt any drastic change and how you are consuming certain things, whether it’s a medication or a diet or a supplement.” — Hussein Yassine, M.D.

Does vitamin D deficiency raise COVID-19 risk?

Expectations for vitamin D and COVID-19

A few things worth checking out: 12-13-2020

COVID-19 vaccine concerns; visualizing cell signaling pathways; IQ points

#140 – Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implications

“If we can understand insulin resistance, then that’s going to be the best way to fix diabetes, heart disease,. . .fatty liver disease, and slow down cancers.” — Gerald Shulman

A few things worth sharing: 11-29-2020

Novel cancer therapy 17-year roundup; AI designed to deceive

#138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives

“Believe it or not, there are 46 million Americans with Alzheimer’s disease in their brain right now, but no symptoms.” — Richard Isaacson

Q&A on Alzheimer’s disease drug therapy with Dr. Richard Isaacson

Check out more content with neurologist, Richard Isaacson, M.D.: (Oct 1, 2018) #18 – Richard Isaacson, M.D.: Alzheimer’s prevention (Nov…

#137 – Paul Offit, M.D.: An expert perspective on COVID-19 vaccines

“When people talk to me about how nervous they are that antibodies are fading, I’m not sure you should be nervous about it yet. Let’s wait to see what happens as we move forward with these vaccines.” — Paul Offit

Masking emotion in the age of COVID-19

Widespread mask wearing in public has become routine, and, in many places, mandated across the US and around the world. While…

#136 – AMA #17: Body composition methods tour de force, insulin resistance, and Topo Chico

“Skeletal muscles are the greatest reservoir that you have for glucose disposal.” —Peter Attia

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