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Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

#120 – AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

“The function of the mitochondria and mitochondrial health are the ultimate mitigator of neurodegenerative diseases…just by reducing the potential for reactive oxygen species related damage.” — Dom D’Agostino

#117 – Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

“There’s really no evidence so far that says this virus has changed in a way that makes it unlikely a vaccine will work, unlikely that a previous infection will protect you from a second infection–there may be reasons why it won’t, but it won’t be because the virus is changing.” — Stanley Perlman

#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino

COVID framework: How does this thing end?

I tried to explain to my 5-year-old son where we currently stand in this pandemic. His questions are the ones that truly matter right now.

#115 – David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

“As we stand here with the coronavirus epidemic three months old, I think we should have faith that science will find a solution to this.” — David Watkins

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

SARS-CoV-2 and the host response: psychological stress

I’ve been thinking a lot about the role of psychological stress and how it relates to our response to SARS-CoV-2, the virus that causes COVID-19.

#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David

#111 – AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity

“Metabolic health really matters. It is the common thread that links all of these chronic diseases.” — Peter Attia

#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K

“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley

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