Category

Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

#05 – Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer

“I immerse myself in what I’m doing…that’s how we learn.” —Dom D’Agostino

Living with Alzheimer’s

North is to south what the clock is to time
There’s east and there’s west and there’s everywhere life
I know I was born and I know that I’ll die
The in between is mine
I am mine

– Pearl Jam

#03 – Ron Krauss, M.D.: a deep dive into heart disease

“Anybody interested in this field should probably understand the origins.” —Ron Krauss

Podcast, AMA, Lp(a), and Dr. Rosenrosen

Bob Kaplan, my head analyst, had the opportunity to drink all of my espresso while he “asked me anything.”

Does it help to know your coronary artery calcium score?

I read an interesting paper on fitness, cardiovascular disease (CVD), and coronary artery calcium (CAC) scores from the Cooper Center Longitudinal Study. This paper looked at “generally healthy middle-aged men” and associations between their level of aerobic fitness, CAC scores, and risk for CVD. So why was this interesting to me (and by extension, should you care)?

The importance of metabolic syndrome and the man behind it

This condition we now all take for granted was barely understood just 30 years ago.

Fat, cancer, discomfort, and giving

This week we learned there’s often more to the story than the one you’re being told.

Lack of context may fuel spread of unintended consequences

A recent study on diet and prostate cancer suggests we need to be more careful communicating and interpreting information.

A big predictor of heart disease risk that most doctors don’t screen for

The most interesting article I read this week was this paper on the NHLBI’s recommendations to reduce Lp(a)-mediated risk of cardiovascular disease.

Studying Studies: Part I – relative risk vs. absolute risk

Reporting relative risk values alone can be inappropriate and misleading for the individual and the public.

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