#123 – Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19
“I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there’s a better immune response and your symptoms will be milder.” — Joan Mannick
#204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D.
“If you prevent aging and age-related disease, you’re going to compress morbidity, too.” — Nir Barzilai
#246 – AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent
“The thing that concerns me the most with these drugs. . .is this drive towards sarcopenia.” —Peter Attia
#207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin
“It’s really hard to know, in my view, how important sirtuins are as longevity factors…If we accept that, then it’s difficult to know [the importance of] activation of sirtuins by NAD as a longevity mechanism.” —Matt Kaeberlein
Metformin and exercise – déjà vu all over again?
Metformin blunts muscle hypertrophy in response to progressive resistance training
A recent metformin study casts doubts on longevity indications
A new retrospective study contradicts previous evidence of metformin’s potential effects on lifespan extension in a general population, but for real answers, randomized trials are needed.