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Preventing Chronic Disease

One of the foundational lessons we can take away from studying centenarians — those who have lived to the age of 100+ — is that if you want to live longer, you have to live longer without chronic disease, not live longer with chronic disease. Unfortunately, our current healthcare system is primarily geared toward helping you live longer once you develop chronic disease. This, of course, is the opposite of the approach I take with my patients. 

Over 80% of deaths in people over 50 who do not smoke can be grouped into 4 main categories, what I like to call the four horsemen of chronic disease. These are: (1) atherosclerotic disease (comprised of cardiovascular disease and cerebrovascular disease), (2) cancer, (3) neurodegenerative disease (Alzheimer’s disease being the most common), and (4) metabolic disease (a spectrum of everything from hyperinsulinemia to insulin resistance to fatty liver disease to type 2 diabetes).

We have five main longevity tactics at our disposal to affect our longevity: (1) exercise, (2) sleep, (3) nutrition, (4) medications & supplements, and (5) distress tolerance. Below is a collection of podcasts and articles discussing how we can use these tactics to mitigate, prevent, and reverse chronic disease.

Rick Johnson, M.D. on the impact of high blood pressure on chronic disease

This video clip is taken from  Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson…

Rick Johnson, M.D. on the relationship between salt & blood pressure

This video clip is taken from  Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson…

A broader perspective on lung cancer

Not just a “smoker’s disease”

Peter Attia on mitigating and reversing insulin resistance with nutrition

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

Peter Attia on the connection between stress and insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you…

Peter Attia on the role of exercise in mitigating and reversing insulin resistance

This clip is from “Ask Me Anything” (AMA) episode #20, originally released on February 15, 2021. If you’re a member, you…

Qualys #168 – Sleep and insulin resistance with Matthew Walker, Ph.D.

This episode of The Qualys is from podcast #33 — Matthew Walker, Ph.D., on sleep Part III — which was originally released on April 15, 2019.

Qualys #166 – Theories on the origins and evolutionary reasons for insulin resistance

This episode of The Qualys is from podcast #69 — Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease — which was originally released on September 2, 2019.

Qualys #261 – Insulin: The amazing story of its discovery, its effect on cellular metabolism and IGF-1, and why it’s so expensive

This episode of The Qualys is from podcast #69 — Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insights — which was originally released on February 18, 2019.

Qualys #165 – Attempting to define insulin resistance with Nir Barzilai, M.D.

This episode of The Qualys is from podcast #33 — Nir Barzilai, M.D.: How to tame aging — which was originally released on January 7, 2019.

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