February 23, 2022

Insulin Resistance

Peter Attia on mitigating and reversing insulin resistance with nutrition

Read Time < 1 minute

This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020.

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Show Notes

Ways to reverse insulin resistance

Insulin resistance can be combated with all 5 tools in the toolkit: 

  • 1) Pharmacologic agents 
  • 2) stress/cortisol management 
  • 3) sleep strategies  
  • 4) exercise, and 
  • 5) nutrition


5. Nutrition

  • By definition, insulin resistance is a carbohydrate tolerance disorder
  • Any doctor who is clinically taking care of patients will say insulin resistance patients generally respond better to carbohydrate restriction than any other form of restriction
  • They respond very well to calorie restriction by definition typically includes carbohydrate restriction
  • It doesn’t have to be a ketogenic diet 
  • Rather tell everyone to stay under XXX amount of carbs, Peter sets a standard in terms of average blood glucose and a standard deviation from that average
  • Peter uses a Dexcom CGM to monitor this (see podcast episode with Kevin Sayer, CEO of Dexcom)

“As those numbers start to come down and the insulin starts to come down and all these other things start to go, that’s exactly what reversibility looks like.” 


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