January 27, 2019

Diseases

A radical new approach to Alzheimer’s?

Perhaps a bigger takeaway from this article is the approach this particular group takes: a consortium from different fields converging on the problem is likely the right way to address a problem as daunting as Alzheimer’s disease.

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A very interesting article making the rounds this week, covering a potential treatment for Alzheimer’s disease—L-serine—based on a hypothesis that an amino acid produced by cyanobacteria, BMAA, is causing ALS and Alzheimer’s disease (in particular geographic regions).

I don’t know that I buy it, though. It seems plausible, even probable, that “too much” BMAA might be a problem—and in said cases maybe high dose L-serine helps (if you’re wondering, they are talking about 30 g per day!!!). However, as a global hypothesis, I find it, thus far, unconvincing. For starters, there are too many macro observations that don’t line up, such as the overwhelming overlap between AD and vascular pathology and global metabolic pathology, both of which point to a neuronal energy crisis.

That said, it is great to see someone else brazenly pointing out how weak the amyloid hypothesis is. Perhaps a bigger takeaway from this article is the approach this particular group takes: a consortium from different fields converging on the problem is likely the right way to address a problem as daunting as Alzheimer’s disease.

– Peter

Disclaimer: This blog is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this blog or materials linked from this blog is at the user's own risk. The content of this blog is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard, or delay in obtaining, medical advice for any medical condition they may have, and should seek the assistance of their health care professionals for any such conditions.
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