December 10, 2018

Podcast

Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process (EP.32)

“The fundamental rule that works for me is just to throw something at the world. The first line, the first experiment, the first idea, and then, keep at it.” —Siddhartha Mukherjee

by Peter Attia

Read Time 50 minutes

In this episode, Siddhartha Mukherjee, oncologist, researcher, and author of the Pulitzer Prize-winning book, The Emperor of All Maladies: A Biography of Cancer, discusses his writing process, his thoughts about medicine, cancer, immunotherapy, and his recent collaboration on a study combining a ketogenic diet with a drug in mice that provided remarkable and encouraging results.

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We discuss:

  • Sid’s background [5:00];
  • How Sid and Peter met [6:00];
  • Sid’s Pulitzer Prize-winning book: The Emperor of All Maladies [8:00];
  • Sid’s writing process: the tenets of writing [12:30];
  • Our struggle to find preventable, human, chemical carcinogens of substantial impact [23:30];
  • The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak test [26:30];
  • Law #2 of medicine: “Normals” teach us rules; “outliers” teach us laws [32:00];
  • Law #3 of medicine: For every perfect medical experiment, there is a perfect human bias [35:00];
  • The excitement around immunotherapy [38:15];
  • The story of Gleevec [46:00];
  • How does the body’s metabolic state affect cancer? [49:30];
  • Can a nutritional state be exploited and/or a drug sensitivity be exploited through a nutritional intervention? [52:00];
  • How does Sid balance his family, writing, research, laboratory, and patients? [1:00:30]; and
  • More.

Featured image source: Nanotech Magazine

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