Learn more about Peter Attia’s digital program
#272 ‒ Rapamycin: potential longevity benefits, surge in popularity, unanswered questions, and more | David Sabatini, M.D., Ph.D. and Matt Kaeberlein, Ph.D.
“[Rapamycin] is the most robust and reproducible drug that we know about today for impacting not only longevity, but to the extent that we can measure various metrics of healthspan in complex animals, rapamycin also seems to positively impact pretty much every aspect of health span that we measure.” —Matt Kaeberlein
A few things worth checking out: 12-13-2020
COVID-19 vaccine concerns; visualizing cell signaling pathways; IQ points
#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging
“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein
#116 – AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise
“If you restore insulin sensitivity, you’re better able to access and burn fat.” — Dom D’Agostino
#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies
“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White
#108 – AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity
“I think once people enter that seventh and eighth decade, if they haven’t done a lot of consistent preparatory work in the decades prior, it’s alarming how quickly things go south.” —Peter Attia
#66 – Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?
“We have 300 different forms of monogenic mitochondrial diseases. . .and these are terrible diseases and we need therapies for them. . .but it’s also our hope that studying some of them will provide insights into the common form of aging as well.” —Vamsi Mootha
#45 – AMA #4: sleep, jet lag protocol, autophagy, metformin, and more
“Every day in the human body, some 10 billion cells die and are replaced by new cells.” —Nick Lane
The mouse trap: lost in translation?
“The great majority of how we understand disease, and attempt to cure it,” writes Engber, “derives from a couple of rodents.” About 4/5ths of all animal studies reported in biomedical research papers from 1950-2010 were done in rodents (59% in mice, 18% in rats).
#37 – Zubin Damania, M.D.: Revolutionizing healthcare one hilariously inspiring video at a time
“The idea that you can optimize a particular regiment to the goals of that unique patient is the foundation of what we call Health 3.0.” —Zubin Damania