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Podcasts

Mental health

#119 – Terry Real: Breaking the cycle of shame, anger, and depression

“Family pathology rolls from generation to generation like a fire in the woods taking down everything in its path until one person, in one generation, has the courage to turn and face the flames. That person brings peace to his ancestors and spares the children that follow.” — Terry Real

Aging

#118 – Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

“Our approach is to address serious aging-associated diseases, and if we’re successful, the side effect will be longevity.” — Lloyd Klickstein

Fasting

#114 – Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

“I would like to translate what we’ve learned about the role of autophagy in cancer and that involves developing small molecules to inhibit autophagy for cancer therapy.” — Eileen White

Aging

#112 – Ned David, Ph.D.: How cellular senescence influences aging, and what we can do about it

“What you see in these diseases of aging is often the sort of unintended consequences of a system that was absolutely awesome for the young, at the expense of the old.” — Ned David

Diseases

#110 – Lew Cantley, Ph.D.: Cancer metabolism, cancer therapies, and the discovery of PI3K

“If I get a result that suddenly doesn’t make sense, to me that’s more exciting. . .if you figure out why it didn’t work and what was wrong, then that’s where most breakthroughs come from.” — Lew Cantley

Mental models

#109 – John Dudley: The beauty in archery, the love of practice, and a model system for life

“It’s a necessity, not only to archery, but to any sport, for people to recognize the fact that the fundamentals are what makes people good at things.” — John Dudley

Fasting

#108 – AMA #13: 3-day fasting, exogenous ketones, autophagy, and exercise for longevity

“I think once people enter that seventh and eighth decade, if they haven’t done a lot of consistent preparatory work in the decades prior, it’s alarming how quickly things go south.” —Peter Attia

COVID-19

#107 – John Barry: 1918 Spanish flu pandemic—historical account, parallels to today, and lessons

“Society is based on trust. When trust evaporates, society begins to fray.” — John Barry

COVID-19

#106 – Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimism

“All of that makes me very optimistic that we will be able to meet the challenge of this virus without putting any of our hospitals into crisis, that this is going to be a severe challenge for this country, but it’s not something that that is going to break the country.” — Dr. Amesh Adalja, referring to some lesser discussed positive trends

COVID-19

#105 – Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlighted

“The virus isn’t plotting against us. It doesn’t have intelligence. It’s invisible. In order to unite, we have to recognize our shared humanity.” — Paul Conti

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