Category

Nutritional Biochemistry

I often get asked, ‘Which diet works best?’. In my view, this is simply the wrong question. Nutritional biochemistry is a powerful lever in our longevity toolkit, but it is much more than fad diets or the number on the bathroom scale. A better question might be, “how can I use nutrition to support my metabolic health?”

Reframing the goal toward metabolic health is a critical starting point. From there, you can combine general principles of nutrition science (such as how much protein you need) with personalization tactics (such as using a CGM to monitor glucose levels) to build a nutrition plan that makes sense for you.

See the collection of audio clips, podcasts, and articles below to learn more about my nutrition and fasting framework.

To reduce appetite, skip late-night snacks

Two recent randomized trials found that biasing food intake toward the end of the day increases appetite and may reduce energy expenditure.

Non-caffeine components of coffee and their effects on neurodegenerative diseases

Coffee consumption is associated with reduced risk of Alzheimer’s disease and other neurodegenerative processes, but the effect may be more than a matter of caffeine.

#235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D.

Most 40 year olds, 50 year olds, they have pain anyway. So I’d rather be strong and have pain than be weak and have pain.” —Layne Norton

#227 – AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more

“We don’t want to be consuming protein for energy purposes at all. We want to be consuming protein for muscle protein synthesis.” —Peter Attia

#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.

We want weight loss, but we don’t want people to lose any lean mass. Especially if they’re adults.” —Don Layman

hangover cure

A “miracle pill” for hangover prevention?

A quick search for “hangover prevention” will send you down a rabbit hole of advice. While staying hydrated and not drinking too much are obvious solutions, there’s a new hangover pill called Myrkl that’s garnering much attention. In this article, you’ll find out exactly what is in these pills, whether they might actually work (or not), and potential downsides. 

#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D.

It’s really important that we be willing to change our beliefs about nutrition and other aspects of health as more data comes in.” —Matt Kaeberlein

Different effects of fat- vs. carbohydrate-restriction on neural reward signaling

“A calorie is a calorie” seems like a simple and obvious statement. But do different macronutrients vary in their ability to drive obesity? A recent study by Dr. Kevin Hall and colleagues provides new clues – and likely new fodder for debate.

The five main tools for managing blood glucose numbers

This clip is from AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions, originally released on…

Vitamin D(éjà vu): new study, same old problems

For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D, and if it doesn’t, then the treatment and placebo groups are effectively identical. So did the researchers achieve a difference in vitamin D levels over the course of the study?

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