Category

Metabolic disease

One way to think about metabolic disease is as a disorder in fuel processing. Whether we’re talking about hyperinsulinemia or type 2 diabetes, the fundamental problem is that the body is not doing a good job storing and accessing fuel.

I think of the three most deadly chronic diseases — heart disease, cancer, and dementia — as pillars all resting on the foundation of metabolic disease. While complications from metabolic disease often do not directly lead to death, the indirect cost is staggering. Each of the other major pillars of chronic disease is exacerbated and amplified by metabolic dysregulation.

Metabolic disease typically exists on a continuum — progressing from hyperinsulinemia, to insulin resistance, to non-alcoholic fatty liver disease, all the way to type 2 diabetes — and tends to cluster with five signs which make up the diagnostic criteria for Metabolic Syndrome, including: high blood pressure, elevated triglycerides, elevated blood glucose, truncal obesity, and low HDL-cholesterol.

The following is a collection of content that dives deeper into the topic of metabolic health, discussing specific strategies for prevention and treatment.

Metabolic disease

How metabolic health impacts your ‘optimal’ diet

This audio clip is from “Ask Me Anything” (AMA) episode #36 — all things fruits and vegetables, originally released on June 20,…

The five main tools for managing blood glucose numbers

This clip is from AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions, originally released on…

#216 – Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

“My big hope is that we’re going to be able to have some combination of directed, metabolic immune supplements and diet that really work with therapy to treat cancer.” —Josh Rabinowitz

Sugar & Cancer: Does Fructose Cause Cancer?

This clip is from episode #187 – Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory, originally released on December…

Is natural sugar from fruit just as ‘bad’ as added sugar?

This video clip is taken from episode #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D., originally released on…

Metabolic dysfunction case study and a framework for metabolic health

This audio clip is from “Ask Me Anything” (AMA) episode #15 — Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more, originally…

The metabolic benefits of exercise & muscle mass

This video clip is from episode #205 – Energy balance, nutrition, & building muscle with Layne Norton, Ph.D. (Pt.2), originally released…

Is cold exposure beneficial for metabolic health?

A look at whether activating brown fat through cold exposure therapy offers metabolic benefits.

Can a father’s metformin cause birth defects in his sons?

Several studies have examined the effects of both maternal diabetes and maternal metformin exposure on offspring, but prospective fathers have received comparatively little attention. A recent study sought to change that.

#202 – Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodes

“I really think that in 10 years we’re going to basically be using designer-based immunotherapies to eradicate most solid organ metastatic cancers.” —Peter Attia

How deadly is type 2 diabetes?

Diabetes was only the 8th-leading cause of death in 2020. Can it really be possible that diabetes is so “harmless” relative to the other major chronic diseases, or are the CDC reports only the tip of the iceberg?

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