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Mental models

#78 – Sasha Cohen: The price of achievement, and redefining success

“You can be a healthy, functioning human being, or you can be the best in the world at something, but you can’t be both.” — Sasha Cohen

Sleep

#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questions

In this special episode, Matthew Walker returns for his second AMA episode where he provides his expert insight on numerous sleep-related questions directly from listeners. He answers a wide range of questions from the gene that causes the short sleeping phenotype, to the ideal sleeping position, to the optimal temperature for best sleep, to how…

Mental health

#76 – Kyle Kingsbury: Finding meaning, depression, and psychedelics

“[Ayahuasca] shifted more things in me and how I perceived the world than anything else.” — Kyle Kingsbury

Treatments

#75 – David Light: Zantac recall due to cancer concerns – what you need to know

“We have to come to grasp the reality that there are problems in the medication system in generics, potentially even brand, and all sorts of holes that exist in how the system is now for medications. We want to be a part of that solution and work together to ensure that every patient is getting a high quality medication.” — David Light

Mental models

#74 – Jason Fried: Optimizing efficiency and work-life balance

“People brag about how little sleep they get, and how much they work. I don’t understand that…if you really ask them about why they’re working so long, it’s not that there’s more work to do, it’s that there’s less time to do good work, because people’s days are broken into smaller and smaller and smaller chunks of time…And before you know it’s the end of the day and you’ve got nothing done even though you’ve been busy all day.” —Jason Fried

Exercise

#73 – AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more

“The sky is blue, and the trees are green; therefore, I should eat cyanide.” — Peter Attia on the type of brilliant logic people use to suggest you burn more calories while sleeping vs. exercising

Mental health

#72 – Dan Harris: 10% happier – meditation, kindness, and compassion

“Mindfulness is the ability to know what’s happening in your head at any given moment without getting carried away by it.” — Dan Harris

Treatments

#71 – Katherine Eban: Widespread fraud in the generic drug industry

“Generics are supposed to be this great leveler. It’s like the democratization of drugs that the rich and the poor alike can have access to for these great cures. To find out…that the companies cashing in on that image are really selling that short in a very devious way, is painful to realize. It’s a real great public health hope that has a very dark underbelly.” — Katherine Eban

Aging

#70 – David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)

In this episode, David Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, returns to the podcast to discuss the content of his new book, Lifespan: Why We Age – and Why We Don’t Have To. This…

Diseases

#69 – Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadly

“The way we raise our kids early on might actually set a pattern for how much of an accelerated life, or how much of a stressed out nervous system they might have later on. . . a lot of the behavioral patterns that we’re instilling in our kids are kind of setting the foundation for insulin resistance and inflammation early on.” —Ronesh Sinha

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